North American Weekend Box Office
US Box Office 22nd January, 2010
| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Avatar (2009) | $34,944,081 | $58,488,882 | $551,741,499 | -18% | 6 |
| 2 (new) |  | Legion (2010) | $17,501,625 | $17,501,625 | $17,501,625 | new | 1 |
| 3 (2) |  | The Book of Eli (2010) | $15,732,493 | $27,946,192 | $60,735,686 | -52% | 2 |
| 4 (new) |  | Tooth Fairy (2010) | $14,010,409 | $14,010,409 | $14,010,409 | new | 1 |
| 5 (3) |  | The Lovely Bones (2009) | $8,418,192 | $13,770,837 | $31,242,633 | -50% | 7 |
| 6 (5) |  | Sherlock Holmes (2009) | $6,628,069 | $10,994,298 | $191,076,852 | -33% | 5 |
| 7 (4) |  | Alvin and the Chipmunks: The Squeakquel (2009) | $6,403,504 | $11,428,556 | $204,140,348 | -45% | 5 |
| 8 (new) |  | Extraordinary Measures (2010) | $6,012,594 | $6,012,594 | $6,012,594 | new | 1 |
| 9 (7) |  | Its Complicated (2009) | $5,810,025 | $9,605,705 | $98,270,085 | -28% | 5 |
| 10 (6) |  | The Spy Next Door (2010) | $4,584,524 | $8,818,563 | $18,544,619 | -53% | 2 |
| 11 (9) |  | The Blind Side (2010) | $4,166,136 | $6,911,863 | $233,678,402 | -25% | 10 |
| 12 (10) |  | Up In the Air (2009) | $3,902,190 | $6,427,319 | $69,245,716 | -28% | 8 |
| 13 (8) |  | Leap Year (2010) | $2,889,110 | $5,225,615 | $22,855,295 | -51% | 3 |
| 14 (re) | | To Save a Life (2009) | $1,581,517 | $1,581,517 | $1,518,517 | re | 1 |
| 15 (11) |  | Daybreakers (2009) | $1,551,703 | $3,723,043 | $28,096,998 | -70% | 3 |
| 16 (19) |  | Crazy Heart (2009) | $1,353,214 | $1,790,620 | $3,865,689 | 52% | 6 |
| 17 (13) |  | The Princess and the Frog (2010) | $1,292,793 | $2,940,988 | $99,248,026 | -53% | 9 |
| 18 (12) |  | Youth In Revolt (2010) | $819,545 | $2,126,295 | $14,269,450 | -73% | 3 |
| 19 (15) |  | The Young Victoria (2009) | $745,514 | $1,271,708 | $7,376,880 | -22% | 6 |
| 20 (17) |  | A Single Man (2010) | $717,077 | $1,175,997 | $4,466,097 | -15% | 7 |
| 21 (16) |  | The Twilight Saga: New Moon (2009) | $514,025 | $946,125 | $293,175,475 | -45% | 10 |
| 22 (14) |  | The Imaginarium of Doctor Parnassus (2009) | $492,735 | $1,057,414 | $5,882,608 | -54% | 5 |
| 23 (18) |  | Invictus (2009) | $415,583 | $834,754 | $35,805,147 | -48% | 7 |
| 24 (22) | | Broken Embraces (2009) | $371,353 | $578,925 | $3,696,132 | -10% | 10 |
| 25 (21) |  | 2012 (2009) | $335,669 | $545,443 | $165,216,143 | -25% | 11 |
| 26 (new) |  | Veer (2010) | $334,562 | $334,562 | $334,562 | new | 1 |
| 27 (24) |  | Planet 51 (2009) | $324,887 | $530,483 | $40,618,512 | -16% | 10 |
| 28 (20) |  | Nine (2009) | $309,438 | $699,120 | $18,847,587 | -47% | 6 |
| 29 (26) |  | Precious: Based On the Novel Push By Sapphire (2009) | $211,820 | $384,385 | $45,142,926 | -11% | 12 |
| 30 (29) |  | An Education (2009) | $159,234 | $229,409 | $8,616,457 | 7% | 14 |
| 31 (25) |  | 3 Idiots (2009) | $148,745 | $243,826 | $6,297,603 | -54% | 5 |
| 32 (27) |  | Fantastic Mr. Fox (2009) | $145,563 | $263,719 | $20,194,544 | -29% | 11 |
| 33 (23) |  | Did You Hear About the Morgans? (2010) | $126,175 | $295,461 | $29,580,087 | -68% | 6 |
| 34 (39) |  | The White Ribbon (2009) | $114,175 | $172,961 | $446,026 | 32% | 4 |
| 35 (28) |  | Old Dogs (2010) | $112,821 | $190,993 | $48,157,476 | -33% | 9 |
| 36 (31) |  | Couples Retreat (2009) | $107,545 | $154,030 | $109,065,605 | -15% | 14 |
| 37 (40) |  | The Last Station (2010) | $99,270 | $145,944 | $219,667 | 26% | 2 |
| 38 (33) |  | Ninja Assassin (2010) | $96,271 | $161,395 | $37,944,431 | -23% | 9 |
| 39 (32) |  | Cloudy With a Chance of Meatballs (2009) | $91,987 | $158,865 | $124,870,275 | -27% | 16 |
| 40 (37) |  | Under the Sea 3D (2009) | $86,876 | $147,301 | $19,791,997 | -10% | 37 |
| 41 (36) |  | Where the Wild Things Are (2009) | $70,969 | $125,961 | $77,105,362 | -30% | 14 |
| 42 (34) |  | The Road (2010) | $69,102 | $143,868 | $7,761,180 | -44% | 9 |
| 43 (new) | | Creation (2009) | $53,073 | $53,073 | $53,073 | new | 1 |
| 44 (38) |  | A Christmas Carol (2009) | $47,829 | $91,826 | $137,816,456 | -41% | 12 |
| 45 (41) |  | The Men Who Stare At Goats (2009) | $47,080 | $83,602 | $32,374,035 | -32% | 12 |
| 46 (42) |  | Law Abiding Citizen (2009) | $46,423 | $75,867 | $73,293,734 | -24% | 14 |
| 47 (92) | | That Evening Sun (2009) | $35,290 | $35,340 | $83,803 | 99% | 9 |
| 48 (43) |  | Space Station 3D (2002) | $33,930 | $51,680 | $80,773,315 | 6% | 346 |
| 49 (46) | | Fish Tank (2009) | $28,607 | $46,976 | $72,830 | 10% | 2 |
| 50 (48) |  | Magnificent Desolation: Walking On the Moon (2005) | $27,073 | $63,462 | $31,742,466 | 12% | 182 |
| 51 (47) | | Me and Orson Welles (2008) | $23,595 | $38,502 | $1,102,411 | -3% | 9 |
| 52 (45) |  | The Bad Lieutenant: Port of Call - New Orleans (2009) | $20,423 | $34,981 | $1,575,502 | -23% | 10 |
| 53 (49) |  | The Messenger (2009) | $20,254 | $31,810 | $742,460 | 10% | 11 |
| 54 (new) |  | The Girl On the Train (2010) | $19,154 | $19,154 | $19,154 | new | 1 |
| 55 (67) |  | A Town Called Panic (2009) | $18,657 | $20,295 | $44,095 | 86% | 6 |
| 56 (44) | | The Boondock Saints II: All Saints Day (2009) | $18,415 | $36,228 | $10,179,972 | -38% | 13 |
| 57 (35) | | Chance Pe Dance (2010) | $16,618 | $46,271 | $164,188 | -86% | 2 |
| 58 (50) | | Sea Monsters a Prehistoric Adventure () | $15,413 | $26,818 | $22,795,228 | -14% | 97 |
| 59 (53) | | The Secrets of Jonathan Sperry () | $14,434 | $19,093 | $1,204,381 | -7% | 16 |
| 60 (56) |  | The Private Lives of Pippa Lee (2009) | $9,559 | $13,913 | $294,711 | -18% | 9 |
| 61 (57) | | The Maid () | $7,908 | $11,940 | $530,418 | -29% | 14 |
| 62 (52) |  | Deep Sea 3D (2006) | $7,894 | $17,836 | $42,862,200 | -51% | 135 |
| 63 (51) | | Dolphins and Whales 3D Tribes of the Ocean () | $7,530 | $18,021 | $7,302,592 | -57% | 78 |
| 64 (59) | | Coco Before Chanel (2009) | $7,525 | $18,273 | $6,075,032 | -10% | 16 |
| 65 (55) | | House () | $6,343 | $19,219 | $31,251 | -47% | 2 |
| 66 (90) | | 35 Shots of Rum (2009) | $6,262 | $6,897 | $142,256 | 93% | 17 |
| 67 (60) |  | Red Cliff (2008) | $5,715 | $9,726 | $571,327 | -17% | 10 |
| 68 (63) | | Until the Light Takes Us () | $4,817 | $7,085 | $65,094 | 12% | 8 |
| 69 (new) | | Misconceptions (2008) | $3,796 | $3,796 | $3,796 | new | 1 |
| 70 (73) |  | Mystery Team (2009) | $3,459 | $3,813 | $59,184 | 53% | 12 |
| 71 (new) | | Watercolors () | $3,207 | $3,207 | $3,207 | new | 1 |
| 72 (71) |  | The Yes Men Fix the World (2009) | $2,976 | $3,134 | $173,704 | 37% | 14 |
| 73 (61) | | Killing Kasztner () | $2,931 | $5,984 | $64,134 | -52% | 11 |
| 74 (64) |  | 44 Inch Chest (2010) | $1,985 | $4,020 | $8,205 | -53% | 2 |
| 75 (69) | | The Missing Person () | $1,539 | $2,778 | $15,952 | -26% | 7 |
| 76 (75) | | Galapagos () | $1,390 | $1,935 | $17,669,543 | -1% | 265 |
| 77 (96) | | Departures (2008) | $1,350 | $1,440 | $1,494,953 | 90% | 27 |
| 78 (58) | | Sweetgrass () | $1,350 | $6,402 | $34,272 | -86% | 3 |
| 79 (76) |  | Séraphine (2009) | $1,200 | $2,731 | $863,376 | -12% | 26 |
| 80 (new) | | Drool () | $1,199 | $1,199 | $1,199 | new | 1 |
| 81 (new) | | Fashion Victim () | $1,046 | $1,046 | $1,046 | new | 1 |
| 82 (83) |  | The Damned United (2009) | $773 | $2,282 | $445,259 | 3% | 14 |
| 83 (re) |  | The Cove (2009) | $615 | $615 | $849,921 | re | 19 |
| 84 (95) | | Under Our Skin () | $500 | $716 | $94,273 | 65% | 20 |
| 85 (94) | | The Headless Woman () | $465 | $573 | $96,744 | 54% | 11 |
| 86 (82) | | Cloud 9 () | $421 | $682 | $88,881 | -49% | 14 |
| 87 (93) | | The September Issue () | $246 | $406 | $3,818,899 | 2% | 20 |
| 88 (91) | | Waiting For Armageddon () | $228 | $466 | $5,038 | -36% | 3 |
| 89 (79) | | Good Hair (2010) | $212 | $845 | $4,151,251 | -78% | 12 |
| 90 (88) | | The Slammin' Salmon (2009) | $174 | $592 | $41,429 | -63% | 6 |
| 91 (78) | | Amreeka () | $174 | $3,494 | $625,658 | -83% | 17 |
| 92 (77) | | The Beaches of Agnès () | $162 | $305 | $228,517 | -86% | 24 |
| 93 (72) | | Four Seasons Lodge () | $159 | $579 | $48,538 | -91% | 10 |