North American Weekend Box Office
US Box Office 22nd January, 2010
| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Avatar (2009) | $34,944,081 | $58,488,882 | $551,741,499 | -18% | 6 |
| 2 (new) |  | Legion (2010) | $17,501,625 | $17,501,625 | $17,501,625 | new | 1 |
| 3 (2) |  | The Book of Eli (2010) | $15,732,493 | $27,946,192 | $60,735,686 | -52% | 2 |
| 4 (new) |  | Tooth Fairy (2010) | $14,010,409 | $14,010,409 | $14,010,409 | new | 1 |
| 5 (3) |  | The Lovely Bones (2009) | $8,418,192 | $13,770,837 | $31,242,633 | -50% | 7 |
| 6 (5) |  | Sherlock Holmes (2009) | $6,628,069 | $10,994,298 | $191,076,852 | -33% | 5 |
| 7 (4) |  | Alvin and the Chipmunks: The Squeakquel (2009) | $6,403,504 | $11,428,556 | $204,140,348 | -45% | 5 |
| 8 (new) |  | Extraordinary Measures (2010) | $6,012,594 | $6,012,594 | $6,012,594 | new | 1 |
| 9 (7) |  | Its Complicated (2009) | $5,810,025 | $9,605,705 | $98,270,085 | -28% | 5 |
| 10 (6) |  | The Spy Next Door (2010) | $4,584,524 | $8,818,563 | $18,544,619 | -53% | 2 |
| 11 (9) |  | The Blind Side (2010) | $4,166,136 | $6,911,863 | $233,678,402 | -25% | 10 |
| 12 (10) |  | Up In the Air (2009) | $3,902,190 | $6,427,319 | $69,245,716 | -28% | 8 |
| 13 (8) |  | Leap Year (2010) | $2,889,110 | $5,225,615 | $22,855,295 | -51% | 3 |
| 14 (re) | | To Save a Life (2009) | $1,581,517 | $1,581,517 | $1,518,517 | re | 1 |
| 15 (11) |  | Daybreakers (2009) | $1,551,703 | $3,723,043 | $28,096,998 | -70% | 3 |