| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Spider-Man: No Way Home (2021) | £4,477,415 | £9,471,251 | £79,321,181 | -26% | 4 |
| 2 (2) |  | The King's Man (2021) | £905,092 | £1,883,785 | £5,380,412 | -74% | 2 |
| 3 (new) |  | Licorice Pizza (2021) | £879,373 | £879,373 | £879,373 | new | 1 |
| 4 (3) |  | Clifford the Big Red Dog (2021) | £623,074 | £1,384,691 | £7,367,194 | -20% | 5 |
| 5 (4) |  | The Matrix Resurrections (2021) | £513,474 | £1,154,889 | £6,449,812 | -32% | 3 |
| 6 (5) |  | West Side Story (2021) | £404,833 | £853,505 | £5,941,232 | 2% | 5 |
| 7 (new) |  | The 355 (2022) | £366,546 | £366,546 | £366,546 | new | 1 |
| 8 (7) |  | House of Gucci (2021) | £214,743 | £368,791 | £9,122,669 | 35% | 7 |
| 9 (6) |  | Encanto (2021) | £213,516 | £432,055 | £6,600,146 | -12% | 7 |
| 10 (8) |  | Ghostbusters: Afterlife (2021) | £117,398 | £236,222 | £11,289,808 | -8% | 8 |
| 11 (new) |  | Boiling Point (2021) | £79,117 | £79,117 | £79,117 | new | 1 |
| 12 (11) |  | The Electrical Life of Louis Wain (2021) | £66,881 | £172,084 | £257,847 | -22% | 2 |
| 13 (10) |  | '83 (2021) | £34,239 | £75,379 | £526,321 | -60% | 3 |
| 14 (9) |  | Titane (2021) | £29,269 | £74,251 | £196,171 | -76% | 2 |
| 15 (14) |  | No Time To Die (2021) | £26,778 | £39,169 | £96,594,314 | 45% | 15 |