| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Doctor Strange (2016) | £3,445,203 | £6,441,297 | £15,730,195 | -63% | 2 |
| 2 (2) |  | Trolls (2016) | £1,990,129 | £3,191,396 | £17,192,724 | -39% | 3 |
| 3 (new) |  | The Accountant (2016) | £1,623,866 | £1,623,866 | £1,623,866 | new | 1 |
| 4 (new) |  | A Street Cat Named Bob (2016) | £985,557 | £985,557 | £985,557 | new | 1 |
| 5 (new) |  | Nocturnal Animals (2016) | £755,427 | £755,427 | £755,427 | new | 1 |
| 6 (new) |  | The Light Between Ocean's (2016) | £733,421 | £733,421 | £733,421 | new | 1 |
| 7 (4) |  | The Girl On the Train (2016) | £624,453 | £1,538,383 | £21,965,662 | -49% | 5 |
| 8 (3) |  | Jack Reacher Never Go Back (2016) | £575,043 | £1,376,477 | £6,952,611 | -54% | 3 |
| 9 (5) |  | Storks (2016) | £366,888 | £634,506 | £5,871,165 | -50% | 4 |
| 10 (6) |  | Bridget Jones's Baby (2016) | £330,017 | £900,621 | £47,072,016 | -51% | 8 |
| 11 (11) |  | I, Daniel Blake (2016) | £324,572 | £742,088 | £2,070,160 | -32% | 3 |
| 12 (8) | | Ae Dil Hai Mushkil (2016) | £248,211 | £534,594 | £1,151,994 | -60% | 2 |
| 13 (9) |  | Miss Peregrines Home For Peculiar Children (2016) | £232,679 | £409,570 | £11,951,075 | -58% | 6 |
| 14 (7) |  | Inferno (2016) | £215,571 | £642,718 | £7,884,674 | -67% | 4 |
| 15 (10) |  | Ouija: Origin of Evil (2016) | £203,612 | £604,542 | £2,524,013 | -62% | 3 |
| 16 (new) | | Pulimurugan (2016) | £92,030 | £92,030 | £92,030 | new | 1 |
| 17 (new) | | The Bright Stream: Bolshoi 2016 (2016) | £57,358 | £57,358 | £57,358 | new | 1 |
| 18 (14) |  | The BFG (2016) | £21,515 | £36,791 | £30,480,616 | -70% | 16 |
| 19 (new) | | Ostatnia Rodzina (2016) | £21,017 | £21,017 | £21,017 | new | 1 |
| 20 (re) | | Anastasia Royal Opera London 2016/17 (2016) | £19,311 | £19,311 | £324,149 | re | 1 |
| 21 (19) | | My Scientology Movie (2016) | £10,050 | £85,661 | £1,048,777 | -69% | 5 |
| 22 (20) |  | American Honey (2016) | £7,652 | £57,957 | £441,929 | -70% | 4 |
| 23 (new) | | Eksi Elmalar (2016) | £7,101 | £7,101 | £7,101 | new | 1 |
| 24 (30) |  | Supersonic (2016) | £6,146 | £10,261 | £740,665 | -16% | 5 |
| 25 (26) |  | The Beatles: Eight Days a Week - The Touring Years (2016) | £5,341 | £23,223 | £1,108,576 | -40% | 8 |
| 26 (new) |  | You've Been Trumped Too (2016) | £5,284 | £5,284 | £5,284 | new | 1 |
| 27 (new) | | Richard Linklater Dream Is Destiny (2016) | £3,707 | £3,707 | £3,707 | new | 1 |
| 28 (re) |  | Branagh Theatre Live: The Entertainer 2016 (2016) | £3,088 | £3,088 | £624,568 | re | 1 |
| 29 (23) |  | Ethel and Ernest (2016) | £3,042 | £20,857 | £40,059 | -84% | 2 |
| 30 (32) |  | Miss Saigon 25th Anniversary Performance (2016) | £2,708 | £8,343 | £2,029,455 | -44% | 4 |
| 31 (37) |  | Jason Bourne (2016) | £2,688 | £23,002 | £23,154,855 | -7% | 15 |
| 32 (25) |  | Starfish (2016) | £2,169 | £10,321 | £21,013 | -80% | 2 |
| 33 (34) |  | Anthropoid (2016) | £1,573 | £6,147 | £800,707 | -55% | 9 |
| 34 (39) | | King Lear: RSC Live 2016 (2016) | £1,397 | £4,945 | £420,093 | -21% | 4 |
| 35 (new) |  | Someone to Talk To (2016) | £1,272 | £1,272 | £1,272 | new | 1 |
| 36 (31) |  | The Infiltrator (2016) | £1,217 | £3,551 | £1,082,864 | -75% | 8 |
| 37 (new) | | Girls Lost (2016) | £984 | £984 | £984 | new | 1 |
| 38 (new) | | The Darkest Universe (2016) | £904 | £904 | £904 | new | 1 |
| 39 (new) | | Rupture (2016) | £795 | £795 | £795 | new | 1 |
| 40 (38) |  | Swallows and Amazons (2016) | £671 | £4,849 | £3,065,501 | -73% | 12 |
| 41 (29) | | Burn Burn Burn (2016) | £664 | £4,753 | £12,229 | -91% | 2 |
| 42 (new) | | The White Knights (2016) | £658 | £658 | £658 | new | 1 |
| 43 (36) |  | Brotherhood (2016) | £310 | £1,231 | £3,696,120 | -90% | 10 |
| 44 (40) | | Under the Shadow (2016) | £252 | £2,993 | £72,186 | -74% | 6 |
| 45 (41) | | War On Everyone (2016) | £184 | £905 | £413,507 | -72% | 5 |
| 46 (43) | | The Greasy Strangler (2016) | £169 | £177 | £17,213 | -71% | 5 |
| 47 (33) |  | The Girl With All the Gifts (2016) | £155 | £2,416 | £1,072,888 | -96% | 7 |
| 48 (new) | | Ivory Game (2016) | £84 | £84 | £84 | new | 1 |
| 49 (re) |  | Hamlet: NT Live 2015 (2015) | £20 | £20 | £2,923,429 | re | 13 |