| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | The Secret Life of Pets (2016) | £9,580,039 | £9,580,039 | £9,580,039 | new | 1 |
| 2 (new) |  | Independence Day: Resurgence (2016) | £5,067,855 | £5,067,855 | £5,067,855 | new | 1 |
| 3 (1) |  | The Conjuring 2: The Enfield Case (2016) | £1,563,015 | £3,097,191 | £7,735,053 | -66% | 2 |
| 4 (2) |  | Me Before You (2016) | £669,924 | £1,486,129 | £8,023,271 | -32% | 4 |
| 5 (6) |  | The Nice Guys (2016) | £202,580 | £440,017 | £3,467,375 | -51% | 4 |
| 6 (5) |  | Alice Through the Looking Glass (2016) | £189,077 | £402,855 | £9,395,165 | -55% | 5 |
| 7 (4) |  | Teenage Mutant Ninja Turtles: Out of the Shadows (2016) | £185,584 | £344,814 | £5,823,141 | -58% | 4 |
| 8 (7) |  | X-Men: Apocalypse (2016) | £173,187 | £359,786 | £18,120,476 | -54% | 6 |
| 9 (11) |  | The Jungle Book (2016) | £105,258 | £199,777 | £45,629,603 | -55% | 11 |
| 10 (9) |  | The Boss (2016) | £103,033 | £325,489 | £1,603,314 | -65% | 3 |
| 11 (3) |  | Gods of Egypt (2016) | £97,496 | £341,084 | £825,551 | -80% | 2 |
| 12 (10) |  | The Angry Birds Movie (2016) | £95,958 | £190,511 | £9,929,464 | -60% | 7 |
| 13 (8) |  | Warcraft (2016) | £88,744 | £259,969 | £5,947,228 | -72% | 4 |
| 14 (new) | | Elvis & Nixon (2016) | £56,790 | £56,790 | £56,790 | new | 1 |
| 15 (new) | | Sardaarji 2 (2016) | £56,382 | £56,382 | £56,382 | new | 1 |
| 16 (13) |  | Tale of Tales (2015) | £47,051 | £120,087 | £239,397 | -61% | 2 |
| 17 (14) |  | Love and Friendship (2016) | £41,245 | £134,315 | £1,556,461 | -61% | 5 |
| 18 (new) | | The Meddler (2016) | £19,327 | £19,327 | £19,327 | new | 1 |
| 19 (new) |  | Remainder (2016) | £16,569 | £16,569 | £16,569 | new | 1 |
| 20 (new) |  | Adult Life Skills (2016) | £16,252 | £16,252 | £16,252 | new | 1 |
| 21 (new) | | Suburra (2016) | £11,321 | £11,321 | £11,321 | new | 1 |
| 22 (18) |  | Our Kind of Traitor (2016) | £9,750 | £19,131 | £1,187,300 | -43% | 7 |
| 23 (new) | | Ma Ma (2016) | £6,427 | £6,427 | £6,427 | new | 1 |
| 24 (22) |  | Thomas & Friends: The Great Race (2016) | £6,365 | £6,703 | £297,171 | 3% | 6 |
| 25 (26) |  | A Hologram For the King (2016) | £5,483 | £11,340 | £782,929 | 18% | 6 |
| 26 (new) |  | Raman Raghav 2.0 (2016) | £4,650 | £4,650 | £4,650 | new | 1 |
| 27 (20) | | Where You're Meant to Be (2016) | £3,387 | £8,814 | £20,163 | -70% | 2 |
| 28 (19) |  | Florence Foster Jenkins (2016) | £2,402 | £35,787 | £3,123,929 | -79% | 8 |
| 29 (23) |  | Eye In the Sky (2016) | £1,959 | £9,892 | £5,026,117 | -64% | 11 |
| 30 (new) | | Ekk Albela (2016) | £1,398 | £1,398 | £1,398 | new | 1 |
| 31 (new) | | Globe On Screen: Richard II: Shakespeares Globe 2015 (2016) | £1,059 | £1,059 | £1,059 | new | 1 |
| 32 (41) |  | The Man Who Knew Infinity (2016) | £940 | £1,827 | £536,225 | 74% | 12 |
| 33 (40) | | Hamlet: RSC Live 2016 (2016) | £683 | £1,612 | £265,925 | 54% | 3 |
| 34 (30) |  | The Audience: NT Live 2013 (2013) | £678 | £15,033 | £2,245,592 | -73% | 3 |
| 35 (new) |  | Crazy About Tiffany's (2016) | £621 | £621 | £621 | new | 1 |
| 36 (36) |  | Versus: The Life and Films of Ken Loach (2016) | £619 | £1,666 | £34,190 | 9% | 4 |
| 37 (35) |  | Golden Years (2016) | £388 | £6,981 | £76,207 | -38% | 8 |
| 38 (re) | | Il Barbiere Di Siviglia: Glyndebourne 2016 (2016) | £347 | £347 | £169,443 | re | 1 |
| 39 (28) | | Globe On Screen: The Merchant of Venice Shakespeares Globe 2015 (2016) | £214 | £4,354 | £28,817 | -94% | 3 |
| 40 (42) |  | Departure (2016) | £196 | £481 | £19,774 | 13% | 6 |