| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Harry Potter and the Deathly Hallows Part 1 (2010) | £3,739,781 | £5,887,234 | £39,145,114 | -55% | 3 |
| 2 (new) |  | Megamind (2010) | £2,827,502 | £2,827,502 | £2,827,502 | new | 1 |
| 3 (2) |  | Unstoppable (2010) | £859,205 | £1,431,472 | £3,146,343 | -50% | 2 |
| 4 (4) |  | Due Date (2010) | £391,284 | £651,686 | £9,859,973 | -30% | 5 |
| 5 (new) |  | Monsters (2010) | £348,577 | £348,577 | £348,577 | new | 1 |
| 6 (5) |  | The American (2010) | £286,072 | £509,819 | £921,526 | -31% | 2 |
| 7 (3) |  | London Boulevard (2010) | £254,134 | £483,281 | £1,060,505 | -56% | 2 |
| 8 (6) |  | Despicable Me (2010) | £136,358 | £52,956 | £19,447,589 | -44% | 8 |
| 9 (7) |  | The Girl Who Kicked the Hornets Nest (2010) | £113,958 | £219,502 | £438,761 | -48% | 2 |
| 10 (new) |  | The Warriors Way (2010) | £105,389 | £105,389 | £105,389 | new | 1 |
| 11 (new) |  | Of Gods and Men (2010) | £59,379 | £59,379 | £59,379 | new | 1 |
| 12 (8) |  | Jackass 3D (2010) | £49,748 | £139,027 | £5,576,683 | -58% | 5 |
| 13 (13) |  | Alpha and Omega (2010) | £48,167 | £56,760 | £2,996,462 | -17% | 7 |
| 14 (new) |  | Secretariat (2010) | £40,941 | £40,941 | £40,941 | new | 1 |
| 15 (12) |  | Another Year (2010) | £35,349 | £79,732 | £1,523,309 | -41% | 5 |
| 16 (new) |  | Rare Exports: A Christmas Tale (2010) | £32,925 | £32,925 | £32,925 | new | 1 |
| 17 (new) |  | Khelein Hum Jee Jaan Sey (2010) | £14,420 | £14,420 | £14,420 | new | 1 |
| 18 (new) |  | Miral (2010) | £12,281 | £12,281 | £12,281 | new | 1 |
| 19 (new) | | Chikku Bukku (2010) | £12,113 | £12,113 | £12,113 | new | 1 |
| 20 (16) |  | Made In Dagenham (2010) | £5,116 | £14,773 | £3,646,258 | -42% | 10 |
| 21 (new) | | Mar Jawan Gur Khake (2010) | £4,905 | £4,905 | £4,905 | new | 1 |
| 22 (17) |  | Burke and Hare (2010) | £3,696 | £9,920 | £2,339,071 | -43% | 5 |
| 23 (new) | | The Be All and End All (2010) | £3,477 | £3,477 | £3,477 | new | 1 |
| 24 (22) | | Africa United (2010) | £1,575 | £2,469 | £670,927 | 5% | 7 |
| 25 (new) | | Freakonomics (2010) | £1,274 | £1,274 | £1,274 | new | 1 |
| 26 (new) | | Easier With Practice (2010) | £987 | £987 | £987 | new | 1 |
| 27 (re) | | Robinson In Ruins (2010) | £887 | £887 | £12,559 | re | 1 |
| 28 (28) | | The Arbor (2010) | £828 | £1,098 | £59,973 | 97% | 7 |
| 29 (23) | | The Illusionist (2010) | £698 | £1,743 | £906,591 | -46% | 15 |
| 30 (new) | | Bathory (2010) | £528 | £528 | £528 | new | 1 |
| 31 (new) | | The Legend of the Fist: The Return of Chen Zhen (2010) | £124 | £124 | £124 | new | 1 |
| 32 (26) |  | Mr. Nice (2010) | £110 | £680 | £763,901 | -57% | 9 |
| 33 (new) |  | Lemmy (2010) | £83 | £83 | £83 | new | 1 |
| 34 (27) | | Over Your Cities Grass Will Grow (2010) | £20 | £126 | £12,011 | -66% | 8 |