| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Due Date (2010) | £1,898,324 | £3,406,790 | £5,752,879 | -19% | 2 |
| 2 (new) |  | Skyline (2010) | £1,206,207 | £1,206,207 | £1,206,207 | new | 1 |
| 3 (3) |  | Despicable Me (2010) | £1,089,160 | £1,308,532 | £18,171,850 | -8% | 5 |
| 4 (2) |  | Jackass 3D (2010) | £1,059,714 | £2,304,491 | £4,001,400 | -38% | 2 |
| 5 (4) |  | Saw: The Final Chapter (2010) | £537,953 | £1,163,845 | £7,571,925 | -50% | 3 |
| 6 (6) |  | Red (2010) | £509,973 | £814,322 | £6,368,199 | -14% | 4 |
| 7 (7) |  | The Social Network (2010) | £422,895 | £751,465 | £9,781,396 | -22% | 5 |
| 8 (5) |  | Paranormal Activity 2 (2010) | £392,009 | £730,478 | £10,606,732 | -43% | 4 |
| 9 (13) |  | Alpha and Omega (2010) | £298,311 | £321,660 | £2,639,841 | 23% | 4 |
| 10 (9) |  | Another Year (2010) | £297,309 | £558,429 | £914,055 | -16% | 2 |
| 11 (8) |  | Let Me In (2010) | £292,988 | £606,904 | £1,095,076 | -40% | 2 |
| 12 (10) |  | Burke and Hare (2010) | £196,229 | £403,389 | £2,144,104 | -41% | 3 |
| 13 (14) |  | Legend of the Guardians: The Owls of Ga'hoole (2010) | £187,684 | £228,047 | £3,041,566 | -14% | 4 |
| 14 (12) |  | The Kids Are All Right (2010) | £161,374 | £330,109 | £1,311,366 | -35% | 3 |
| 15 (new) |  | You Again (2010) | £145,034 | £145,034 | £145,034 | new | 1 |