| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Paranormal Activity 2 (2010) | £3,764,722 | £3,764,722 | £3,764,722 | new | 1 |
| 2 (1) |  | Despicable Me (2010) | £2,589,170 | £3,920,972 | £7,585,348 | -29% | 2 |
| 3 (new) |  | Red (2010) | £1,662,472 | £1,662,472 | £1,662,472 | new | 1 |
| 4 (2) |  | The Social Network (2010) | £1,538,571 | £2,872,655 | £5,359,109 | -38% | 2 |
| 5 (new) |  | Legend of the Guardians: The Owls of Ga'hoole (2010) | £737,444 | £737,444 | £737,444 | new | 1 |
| 6 (new) |  | Alpha and Omega (2010) | £643,425 | £643,425 | £643,425 | new | 1 |
| 7 (3) |  | Vampires Suck (2010) | £530,136 | £935,470 | £2,024,809 | -51% | 2 |
| 8 (new) |  | Easy A (2010) | £277,975 | £277,975 | £277,975 | new | 1 |
| 9 (5) |  | Life As We Know It (2010) | £263,134 | £656,276 | £2,919,246 | -58% | 3 |
| 10 (4) |  | Wall Street: Money Never Sleeps (2010) | £258,968 | £614,070 | £3,698,077 | -62% | 3 |
| 11 (new) | | Africa United (2010) | £177,827 | £177,827 | £177,827 | new | 1 |
| 12 (7) |  | Made In Dagenham (2010) | £156,712 | £455,315 | £3,021,619 | -54% | 4 |
| 13 (6) |  | The Town (2010) | £126,777 | £325,624 | £4,771,263 | -63% | 5 |
| 14 (new) | | Ramona and Beezus (2010) | £84,475 | £84,475 | £84,475 | new | 1 |
| 15 (8) |  | The Other Guys (2010) | £75,250 | £250,681 | £8,035,897 | -77% | 6 |
| 16 (11) |  | Mr. Nice (2010) | £38,048 | £129,723 | £658,257 | -72% | 3 |
| 17 (new) |  | Jhootha Hi Sahi (2010) | £32,685 | £32,685 | £32,685 | new | 1 |
| 18 (new) | | The Arbor (2010) | £16,883 | £16,883 | £16,883 | new | 1 |
| 19 (new) | | Mary and Max (2010) | £12,052 | £12,052 | £12,052 | new | 1 |
| 20 (new) | | Hisss (2010) | £8,519 | £8,519 | £8,519 | new | 1 |
| 21 (20) | | The Illusionist (2010) | £5,662 | £14,183 | £855,651 | 13% | 10 |
| 22 (18) |  | Tamara Drewe (2010) | £5,039 | £16,494 | £2,537,217 | -49% | 7 |
| 23 (22) |  | Soulboy (2010) | £1,690 | £4,520 | £81,296 | -46% | 6 |
| 24 (21) | | Over Your Cities Grass Will Grow (2010) | £646 | £3,271 | £7,635 | -85% | 2 |
| 25 (new) | | Cehennem 3D (2010) | £597 | £597 | £597 | new | 1 |