| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Despicable Me (2010) | £3,664,376 | £3,664,376 | £3,664,376 | new | 1 |
| 2 (new) |  | The Social Network (2010) | £2,486,454 | £2,486,454 | £2,486,454 | new | 1 |
| 3 (new) |  | Vampires Suck (2010) | £1,089,339 | £1,089,339 | £1,089,339 | new | 1 |
| 4 (1) |  | Wall Street: Money Never Sleeps (2010) | £675,549 | £1,299,698 | £3,084,007 | -62% | 2 |
| 5 (2) |  | Life As We Know It (2010) | £624,367 | £1,277,412 | £2,262,970 | -37% | 2 |
| 6 (5) |  | The Town (2010) | £343,620 | £697,178 | £4,445,639 | -41% | 4 |
| 7 (7) |  | Made In Dagenham (2010) | £343,222 | £775,374 | £2,566,304 | -32% | 3 |
| 8 (4) |  | The Other Guys (2010) | £332,064 | £653,588 | £7,785,216 | -48% | 5 |
| 9 (3) |  | The Death and Life of Charlie St Cloud (2010) | £314,873 | £655,868 | £1,299,236 | -51% | 2 |
| 10 (8) |  | Eat Pray Love (2010) | £153,276 | £460,805 | £4,291,302 | -62% | 4 |
| 11 (11) |  | Mr. Nice (2010) | £134,846 | £288,690 | £528,534 | -44% | 2 |
| 12 (9) |  | Buried (2010) | £124,157 | £320,757 | £1,873,313 | -62% | 3 |
| 13 (6) |  | The Hole (2010) | £107,846 | £241,869 | £2,812,547 | -79% | 4 |
| 14 (10) |  | Toy Story 3 (2010) | £83,460 | £139,539 | £73,405,113 | -68% | 13 |
| 15 (12) |  | Marmaduke (2010) | £67,188 | £110,479 | £5,451,919 | -67% | 9 |
| 16 (new) | | Aakrosh (2010) | £30,794 | £30,794 | £30,794 | new | 1 |
| 17 (19) |  | Cats & Dogs: The Revenge of Kitty Galore (2010) | £19,442 | £101,471 | £6,349,161 | 4% | 5 |
| 18 (18) |  | Tamara Drewe (2010) | £9,914 | £35,928 | £2,520,723 | -57% | 6 |
| 19 (new) | | Knock Out (2010) | £8,308 | £8,308 | £8,308 | new | 1 |
| 20 (23) | | The Illusionist (2010) | £4,930 | £16,779 | £841,468 | -33% | 9 |
| 21 (new) | | Over Your Cities Grass Will Grow (2010) | £4,364 | £4,364 | £4,364 | new | 1 |
| 22 (27) |  | Soulboy (2010) | £3,130 | £4,182 | £76,776 | 98% | 5 |
| 23 (25) | | The Wildest Dream Conquest of Everest (2010) | £1,140 | £4,367 | £24,957 | -58% | 3 |
| 24 (24) | | Jackboots On Whitehall (2010) | £87 | £3,134 | £7,847 | -98% | 2 |