| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | The Other Guys (2010) | £1,980,601 | £1,980,601 | £1,980,601 | new | 1 |
| 2 (new) |  | Devil (2010) | £807,292 | £807,292 | £807,292 | new | 1 |
| 3 (1) |  | Resident Evil: Afterlife (2010) | £727,908 | £1,640,185 | £3,330,840 | -57% | 2 |
| 4 (2) |  | Toy Story 3 (2010) | £583,013 | £792,800 | £71,807,948 | -23% | 9 |
| 5 (3) |  | Grown Ups (2010) | £513,881 | £855,617 | £6,300,322 | -31% | 4 |
| 6 (5) |  | Tamara Drewe (2010) | £432,337 | £932,628 | £1,548,181 | -30% | 2 |
| 7 (4) |  | The Last Exorcism (2010) | £321,585 | £689,264 | £3,180,800 | -56% | 3 |
| 8 (13) |  | Marmaduke (2010) | £279,392 | £147,986 | £4,686,910 | -9% | 5 |
| 9 (new) | | Winter's Bone (2010) | £267,408 | £267,408 | £267,408 | new | 1 |
| 10 (15) |  | Diary of a Wimpy Kid (2010) | £241,390 | £265,456 | £2,058,757 | -9% | 4 |
| 11 (6) |  | Scott Pilgrim Vs. the World (2010) | £233,228 | £473,543 | £4,812,773 | -47% | 4 |
| 12 (7) |  | Going the Distance (2010) | £220,359 | £593,015 | £1,029,376 | -50% | 2 |
| 13 (14) |  | Inception (2010) | £201,162 | £367,112 | £34,976,999 | -26% | 10 |
| 14 (11) |  | Salt (2010) | £190,011 | £388,356 | £6,737,499 | -45% | 5 |
| 15 (8) |  | Cyrus (2010) | £172,584 | £488,811 | £918,730 | -60% | 2 |
| 16 (10) |  | The Expendables (2010) | £160,147 | £386,755 | £9,630,137 | -56% | 5 |
| 17 (new) |  | Just Wright (2010) | £82,513 | £82,513 | £82,513 | new | 1 |
| 18 (new) | | The Kid (2010) | £22,974 | £22,974 | £22,974 | new | 1 |
| 19 (new) |  | I'm Still Here (2010) | £22,730 | £22,730 | £22,730 | new | 1 |
| 20 (17) | | The Illusionist (2010) | £22,435 | £60,535 | £749,240 | -49% | 5 |
| 21 (new) | | Ik Kudi Punjab Di (2010) | £19,683 | £19,683 | £19,683 | new | 1 |
| 22 (re) |  | Soulboy (2010) | £11,248 | £11,248 | £43,144 | re | 1 |
| 23 (new) | | Savage (2010) | £6,744 | £6,744 | £6,744 | new | 1 |
| 24 (new) |  | F (2010) | £6,103 | £6,103 | £6,103 | new | 1 |
| 25 (new) | | Night of the Demon's (2010) | £1,959 | £1,959 | £1,959 | new | 1 |
| 26 (new) | | A Distant Mirage (2010) | £638 | £638 | £638 | new | 1 |
| 27 (20) | | Bonded By Blood (2010) | £356 | £2,327 | £52,991 | -92% | 3 |
| 28 (new) |  | The Horde (2010) | £336 | £336 | £336 | new | 1 |
| 29 (22) | | London River (2010) | £8 | £2,267 | £97,536 | -99% | 11 |