| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Resident Evil: Afterlife (2010) | £1,690,655 | £1,690,655 | £1,690,655 | new | 1 |
| 2 (3) |  | Toy Story 3 (2010) | £756,575 | £1,136,772 | £71,015,148 | -19% | 8 |
| 3 (4) |  | Grown Ups (2010) | £742,472 | £1,250,695 | £5,444,705 | -15% | 3 |
| 4 (1) |  | The Last Exorcism (2010) | £730,395 | £1,386,680 | £2,491,536 | -34% | 2 |
| 5 (new) |  | Tamara Drewe (2010) | £615,553 | £615,553 | £615,553 | new | 1 |
| 6 (5) |  | Scott Pilgrim Vs. the World (2010) | £439,143 | £946,937 | £4,339,230 | -37% | 3 |
| 7 (new) |  | Going the Distance (2010) | £436,361 | £436,361 | £436,361 | new | 1 |
| 8 (new) |  | Cyrus (2010) | £429,919 | £429,919 | £429,919 | new | 1 |
| 9 (2) |  | Dinner For Schmucks (2010) | £401,567 | £926,623 | £1,867,209 | -57% | 2 |
| 10 (7) |  | The Expendables (2010) | £366,663 | £795,704 | £9,243,382 | -42% | 4 |
| 11 (8) |  | Salt (2010) | £342,575 | £680,562 | £6,349,143 | -33% | 4 |
| 12 (new) |  | Dabangg (2010) | £332,673 | £332,673 | £332,673 | new | 1 |
| 13 (11) |  | Marmaduke (2010) | £305,663 | £258,994 | £4,538,924 | -16% | 4 |
| 14 (10) |  | Inception (2010) | £271,033 | £554,534 | £34,609,887 | -35% | 9 |
| 15 (12) |  | Diary of a Wimpy Kid (2010) | £265,068 | £341,269 | £1,793,301 | -14% | 3 |
| 16 (new) | | The Runaways (2010) | £59,443 | £59,443 | £59,443 | new | 1 |
| 17 (17) | | The Illusionist (2010) | £44,336 | £99,403 | £688,705 | -33% | 4 |
| 18 (new) |  | Boss Engira Bhaskaran (2010) | £20,765 | £20,765 | £20,765 | new | 1 |
| 19 (new) | | My Son, My Son, What Have Ye Done (2010) | £6,815 | £6,815 | £6,815 | new | 1 |
| 20 (20) | | Bonded By Blood (2010) | £4,449 | £24,774 | £50,664 | -83% | 2 |
| 21 (new) | | Alamar (2010) | £2,830 | £2,830 | £2,830 | new | 1 |
| 22 (28) | | London River (2010) | £1,487 | £3,085 | £95,269 | 36% | 10 |
| 23 (25) |  | Cherry Tree Lane (2010) | £422 | £2,138 | £3,425 | -67% | 2 |