| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | The Last Exorcism (2010) | £1,104,856 | £1,104,856 | £1,104,856 | new | 1 |
| 2 (new) |  | Dinner For Schmucks (2010) | £940,586 | £940,586 | £940,586 | new | 1 |
| 3 (3) |  | Toy Story 3 (2010) | £934,423 | £2,285,161 | £69,878,376 | -38% | 7 |
| 4 (1) |  | Grown Ups (2010) | £878,141 | £2,187,065 | £4,194,010 | -56% | 2 |
| 5 (2) |  | Scott Pilgrim Vs. the World (2010) | £702,542 | £1,787,748 | £3,392,293 | -56% | 2 |
| 6 (new) |  | The Switch (2010) | £666,018 | £666,018 | £666,018 | new | 1 |
| 7 (4) |  | The Expendables (2010) | £627,776 | £1,631,264 | £8,447,678 | -52% | 3 |
| 8 (5) |  | Salt (2010) | £509,319 | £1,284,963 | £5,668,581 | -47% | 3 |
| 9 (6) |  | Piranha 3D (2010) | £446,895 | £1,178,546 | £4,466,428 | -50% | 3 |
| 10 (7) |  | Inception (2010) | £417,302 | £969,495 | £34,055,353 | -40% | 8 |
| 11 (10) |  | Marmaduke (2010) | £364,098 | £1,341,469 | £4,279,930 | -38% | 3 |
| 12 (8) |  | Diary of a Wimpy Kid (2010) | £307,031 | £780,871 | £1,452,032 | -54% | 2 |
| 13 (9) |  | Avatar (2009) | £274,145 | £629,517 | £93,442,625 | -56% | 18 |
| 14 (12) |  | The Girl Who Played With Fire (2010) | £216,472 | £500,493 | £905,389 | -47% | 2 |
| 15 (new) | | We Are Family (2010) | £162,863 | £162,863 | £162,863 | new | 1 |
| 16 (new) | | Certified Copy (2010) | £76,703 | £76,703 | £76,703 | new | 1 |
| 17 (16) | | The Illusionist (2010) | £66,160 | £151,810 | £589,302 | -35% | 3 |
| 18 (new) |  | Why Did I Get Married Too? (2010) | £41,459 | £41,459 | £41,459 | new | 1 |
| 19 (new) |  | Jonah Hex (2010) | £36,456 | £36,456 | £36,456 | new | 1 |
| 20 (new) | | Bonded By Blood (2010) | £25,890 | £25,890 | £25,890 | new | 1 |
| 21 (21) |  | Nanny Mcphee and the Big Bang (2010) | £11,273 | £11,364 | £16,524,872 | 88% | 24 |
| 22 (new) | | Soul Boy (2010) | £9,027 | £9,027 | £9,027 | new | 1 |
| 23 (new) | | 22 Bullets (2010) | £4,528 | £4,528 | £4,528 | new | 1 |
| 24 (new) | | Chhevan Dariya (2010) | £2,103 | £2,103 | £2,103 | new | 1 |
| 25 (new) |  | Cherry Tree Lane (2010) | £1,287 | £1,287 | £1,287 | new | 1 |
| 26 (new) |  | No Impact Man (2010) | £1,006 | £1,006 | £1,006 | new | 1 |
| 27 (new) | | Splintered (2010) | £996 | £996 | £996 | new | 1 |
| 28 (22) | | London River (2010) | £953 | £2,754 | £92,184 | 27% | 9 |