| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | The Expendables (2010) | £3,910,596 | £3,910,596 | £3,910,596 | new | 1 |
| 2 (new) |  | Salt (2010) | £2,166,715 | £2,166,715 | £2,166,715 | new | 1 |
| 3 (1) |  | Toy Story 3 (2010) | £2,090,277 | £2,838,153 | £61,746,551 | -34% | 5 |
| 4 (new) |  | Piranha 3D (2010) | £1,487,119 | £1,487,119 | £1,487,119 | new | 1 |
| 5 (new) |  | Marmaduke (2010) | £1,243,789 | £1,243,789 | £1,243,789 | new | 1 |
| 6 (2) |  | Inception (2010) | £1,063,679 | £2,359,821 | £31,563,941 | -37% | 6 |
| 7 (4) |  | Knight and Day (2010) | £825,692 | £2,044,533 | £7,953,038 | -46% | 3 |
| 8 (3) |  | The Last Airbender (2010) | £586,576 | £1,656,329 | £3,310,105 | -65% | 2 |
| 9 (6) |  | Step Up 3D (2010) | £507,942 | £1,689,928 | £6,636,616 | -53% | 3 |
| 10 (5) |  | The Sorcerers Apprentice (2010) | £439,527 | £1,230,003 | £2,370,535 | -61% | 2 |
| 11 (7) |  | The Karate Kid (2010) | £382,276 | £1,012,861 | £11,613,244 | -50% | 4 |
| 12 (8) |  | The A-Team (2010) | £333,549 | £919,433 | £9,835,019 | -56% | 4 |
| 13 (9) |  | Cats & Dogs: The Revenge of Kitty Galore (2010) | £190,661 | £750,171 | £3,968,663 | -61% | 3 |
| 14 (10) |  | Tinker Bell and the Great Fairy Rescue (2010) | £181,680 | £459,949 | £748,493 | -37% | 2 |
| 15 (new) | | The Illusionist (2010) | £161,900 | £161,900 | £161,900 | new | 1 |