| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Toy Story 3 (2010) | £3,162,944 | £7,383,879 | £58,908,398 | -32% | 4 |
| 2 (3) |  | Inception (2010) | £1,681,130 | £3,484,476 | £29,204,120 | -26% | 5 |
| 3 (new) |  | The Last Airbender (2010) | £1,653,776 | £1,653,776 | £1,653,776 | new | 1 |
| 4 (2) |  | Knight and Day (2010) | £1,529,478 | £3,504,342 | £5,908,505 | -36% | 2 |
| 5 (new) |  | The Sorcerers Apprentice (2010) | £1,140,532 | £1,140,532 | £1,140,532 | new | 1 |
| 6 (4) |  | Step Up 3D (2010) | £1,078,100 | £2,931,285 | £4,946,688 | -47% | 2 |
| 7 (6) |  | The Karate Kid (2010) | £764,748 | £2,034,304 | £10,600,383 | -46% | 3 |
| 8 (7) |  | The A-Team (2010) | £762,570 | £1,873,945 | £8,915,586 | -45% | 3 |
| 9 (5) |  | Cats & Dogs: The Revenge of Kitty Galore (2010) | £488,905 | £1,665,487 | £3,218,492 | -69% | 2 |
| 10 (new) |  | Tinker Bell and the Great Fairy Rescue (2010) | £288,544 | £288,544 | £288,544 | new | 1 |
| 11 (8) |  | Shrek Forever After (2010) | £246,835 | £638,049 | £31,106,087 | -32% | 7 |
| 12 (9) |  | The Twilight Saga: Eclipse (2010) | £148,549 | £437,969 | £29,308,657 | -54% | 6 |
| 13 (new) |  | The Secret In Their Eyes (2010) | £85,467 | £85,467 | £85,467 | new | 1 |
| 14 (11) | | Coco Chanel and Igor Stravinsky (2010) | £43,426 | £94,986 | £147,860 | -18% | 2 |
| 15 (10) | | Gainsbourg (2010) | £41,128 | £121,865 | £465,332 | -53% | 3 |
| 16 (new) | | Le Refuge (2010) | £13,808 | £13,808 | £13,808 | new | 1 |
| 17 (16) |  | Nanny Mcphee and the Big Bang (2010) | £9,009 | £9,232 | £16,460,428 | -15% | 21 |
| 18 (new) |  | Black Dynamite (2010) | £6,400 | £6,400 | £6,400 | new | 1 |
| 19 (18) | | London River (2010) | £4,097 | £10,438 | £79,434 | 18% | 6 |
| 20 (23) |  | The Ghost (2010) | £854 | £1,809 | £4,075,697 | -38% | 18 |
| 21 (19) |  | Down Terrace (2010) | £783 | £1,944 | £7,230 | -63% | 3 |
| 22 (new) | | The Final (2010) | £228 | £228 | £228 | new | 1 |