| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Toy Story 3 (2010) | £4,666,021 | £11,733,296 | £51,524,519 | -43% | 3 |
| 2 (new) |  | Knight and Day (2010) | £2,404,163 | £2,404,163 | £2,404,163 | new | 1 |
| 3 (4) |  | Inception (2010) | £2,259,595 | £4,919,176 | £25,719,644 | -30% | 4 |
| 4 (new) |  | Step Up 3D (2010) | £2,015,403 | £2,015,403 | £2,015,403 | new | 1 |
| 5 (new) |  | Cats & Dogs: The Revenge of Kitty Galore (2010) | £1,553,005 | £1,553,005 | £1,553,005 | new | 1 |
| 6 (2) |  | The Karate Kid (2010) | £1,411,486 | £3,683,773 | £8,566,079 | -71% | 2 |
| 7 (3) |  | The A-Team (2010) | £1,386,868 | £3,472,136 | £7,041,641 | -61% | 2 |
| 8 (5) |  | Shrek Forever After (2010) | £362,464 | £1,274,498 | £30,468,038 | -60% | 6 |
| 9 (6) |  | The Twilight Saga: Eclipse (2010) | £324,469 | £1,089,429 | £28,870,688 | -58% | 5 |
| 10 (8) | | Gainsbourg (2010) | £87,125 | £208,436 | £343,467 | -35% | 2 |
| 11 (new) | | Coco Chanel and Igor Stravinsky (2010) | £52,874 | £52,874 | £52,874 | new | 1 |
| 12 (new) | | Aisha (2010) | £52,759 | £52,759 | £52,759 | new | 1 |
| 13 (14) |  | Tooth Fairy (2010) | £32,216 | £70,277 | £3,866,018 | 14% | 10 |
| 14 (7) |  | The Rebound (2010) | £28,913 | £207,148 | £1,123,719 | -84% | 3 |
| 15 (9) |  | Predators (2010) | £23,129 | £128,115 | £5,767,854 | -79% | 5 |
| 16 (17) |  | Nanny Mcphee and the Big Bang (2010) | £10,603 | £11,184 | £16,451,196 | 4% | 20 |
| 17 (new) | | Undertow (2010) | £9,896 | £9,896 | £9,896 | new | 1 |
| 18 (22) | | London River (2010) | £3,373 | £6,676 | £68,996 | 26% | 5 |
| 19 (24) |  | Down Terrace (2010) | £2,125 | £3,367 | £5,286 | 10% | 2 |
| 20 (21) |  | Four Lions (2010) | £1,759 | £3,482 | £2,932,366 | -38% | 14 |
| 21 (new) |  | Eccentricities of a Blonde Haired Girl (2010) | £1,645 | £1,645 | £1,645 | new | 1 |
| 22 (20) |  | Robin Hood (2010) | £1,453 | £4,775 | £15,440,353 | -54% | 13 |
| 23 (23) |  | The Ghost (2010) | £1,373 | £2,340 | £4,073,888 | -38% | 17 |
| 24 (new) |  | Mummy and Me (2010) | £830 | £830 | £830 | new | 1 |
| 25 (19) |  | StreetDance 3D (2010) | £532 | £2,289 | £11,617,687 | -85% | 12 |
| 26 (28) |  | 4.3.2.1 (2010) | £235 | £335 | £984,375 | 90% | 10 |