| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Toy Story 3 (2010) | £8,115,193 | £18,603,959 | £39,791,223 | -62% | 2 |
| 2 (new) |  | The Karate Kid (2010) | £4,882,306 | £4,882,306 | £4,882,306 | new | 1 |
| 3 (new) |  | The A-Team (2010) | £3,569,505 | £3,569,505 | £3,569,505 | new | 1 |
| 4 (2) |  | Inception (2010) | £3,229,651 | £6,595,947 | £20,800,468 | -23% | 3 |
| 5 (4) |  | Shrek Forever After (2010) | £899,851 | £2,314,819 | £29,193,540 | -26% | 5 |
| 6 (3) |  | The Twilight Saga: Eclipse (2010) | £779,142 | £2,144,954 | £27,781,259 | -46% | 4 |
| 7 (5) |  | The Rebound (2010) | £178,972 | £556,556 | £916,571 | -50% | 2 |
| 8 (new) | | Gainsbourg (2010) | £135,031 | £135,031 | £135,031 | new | 1 |
| 9 (6) |  | Predators (2010) | £112,088 | £337,397 | £5,639,739 | -63% | 4 |
| 10 (new) | | Once Upon a Time In Mumbaai (2010) | £54,780 | £54,780 | £54,780 | new | 1 |
| 11 (7) | | Khatta Meetha (2010) | £46,851 | £125,101 | £249,205 | -62% | 2 |
| 12 (8) |  | Get Him to the Greek (2010) | £44,001 | £137,098 | £6,946,757 | -63% | 6 |
| 13 (9) | | Splice (2010) | £34,478 | £129,313 | £239,538 | -69% | 2 |
| 14 (re) |  | Tooth Fairy (2010) | £27,576 | £27,576 | £3,795,741 | re | 9 |
| 15 (11) | | Heartbreaker (2010) | £21,519 | £56,435 | £596,009 | -39% | 5 |