| Title | Weekend | Week | Total | % Change | Total Weeks | ||
| 1 (new) | ![]() | Toy Story 3 (2010) | £21,187,264 | £21,187,264 | £21,187,264 | new | 1 |
| 2 (1) | ![]() | Inception (2010) | £4,172,568 | £8,291,707 | £14,204,521 | -29% | 2 |
| 3 (3) | ![]() | The Twilight Saga: Eclipse (2010) | £1,436,792 | £3,536,389 | £25,636,305 | -58% | 3 |
| 4 (2) | ![]() | Shrek Forever After (2010) | £1,223,759 | £2,481,288 | £26,878,721 | -71% | 4 |
| 5 (new) | ![]() | The Rebound (2010) | £360,015 | £360,015 | £360,015 | new | 1 |
| 6 (4) | ![]() | Predators (2010) | £305,424 | £841,469 | £5,302,342 | -66% | 3 |
| 7 (new) | Khatta Meetha (2010) | £124,104 | £124,104 | £124,104 | new | 1 | |
| 8 (5) | ![]() | Get Him to the Greek (2010) | £119,424 | £337,421 | £6,809,659 | -73% | 5 |
| 9 (new) | Splice (2010) | £110,225 | £110,225 | £110,225 | new | 1 | |
| 10 (9) | Leaving (2010) | £39,409 | £75,439 | £204,525 | -22% | 3 | |
| 11 (7) | Heartbreaker (2010) | £35,431 | £70,378 | £539,574 | -48% | 4 | |
| 12 (10) | The Concert (2010) | £26,268 | £55,626 | £93,679 | -31% | 2 | |
| 13 (12) | Mel Karade Rabba (2010) | £19,892 | £44,651 | £78,646 | -41% | 2 | |
| 14 (re) | ![]() | How to Train Your Dragon (2010) | £17,935 | £17,935 | £17,168,517 | re | 9 |
| 15 (8) | ![]() | Sex and the City 2 (2010) | £15,516 | £39,916 | £21,606,766 | -70% | 9 |
| 16 (new) | ![]() | Thillalangadi (2010) | £13,685 | £13,685 | £13,685 | new | 1 |
| 17 (27) | ![]() | Nanny Mcphee and the Big Bang (2010) | £11,509 | £11,974 | £16,429,100 | 82% | 18 |
| 18 (new) | Baarìa (2009) | £7,385 | £7,385 | £7,385 | new | 1 | |
| 19 (new) | City Island (2009) | £6,936 | £6,936 | £6,936 | new | 1 | |
| 20 (20) | London River (2010) | £5,093 | £12,234 | £52,487 | -43% | 3 | |
| 21 (19) | ![]() | Four Lions (2010) | £4,902 | £13,060 | £2,922,804 | -47% | 12 |
| 22 (17) | ![]() | StreetDance 3D (2010) | £4,293 | £9,076 | £11,604,784 | -69% | 10 |
| 23 (18) | ![]() | Robin Hood (2010) | £2,750 | £11,299 | £15,428,743 | -72% | 11 |
| 24 (new) | Ivul (2010) | £2,327 | £2,327 | £2,327 | new | 1 | |
| 25 (25) | Went the Day Well? (1942) Rerelease | £1,281 | £3,521 | £13,205 | -57% | 2 | |
| 26 (26) | ![]() | The Ghost (2010) | £878 | £3,538 | £4,067,449 | -64% | 15 |
| 27 (22) | ![]() | Wild Target (2010) | £672 | £6,292 | £783,555 | -86% | 5 |
| 28 (29) | ![]() | 4.3.2.1 (2010) | £104 | £281 | £983,863 | -19% | 8 |
| 29 (24) | ![]() | The Killer Inside Me (2010) | £20 | £3,566 | £461,415 | -99% | 8 |