| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Toy Story 3 (2010) | £21,187,264 | £21,187,264 | £21,187,264 | new | 1 |
| 2 (1) |  | Inception (2010) | £4,172,568 | £8,291,707 | £14,204,521 | -29% | 2 |
| 3 (3) |  | The Twilight Saga: Eclipse (2010) | £1,436,792 | £3,536,389 | £25,636,305 | -58% | 3 |
| 4 (2) |  | Shrek Forever After (2010) | £1,223,759 | £2,481,288 | £26,878,721 | -71% | 4 |
| 5 (new) |  | The Rebound (2010) | £360,015 | £360,015 | £360,015 | new | 1 |
| 6 (4) |  | Predators (2010) | £305,424 | £841,469 | £5,302,342 | -66% | 3 |
| 7 (new) | | Khatta Meetha (2010) | £124,104 | £124,104 | £124,104 | new | 1 |
| 8 (5) |  | Get Him to the Greek (2010) | £119,424 | £337,421 | £6,809,659 | -73% | 5 |
| 9 (new) | | Splice (2010) | £110,225 | £110,225 | £110,225 | new | 1 |
| 10 (9) | | Leaving (2010) | £39,409 | £75,439 | £204,525 | -22% | 3 |
| 11 (7) | | Heartbreaker (2010) | £35,431 | £70,378 | £539,574 | -48% | 4 |
| 12 (10) | | The Concert (2010) | £26,268 | £55,626 | £93,679 | -31% | 2 |
| 13 (12) | | Mel Karade Rabba (2010) | £19,892 | £44,651 | £78,646 | -41% | 2 |
| 14 (re) |  | How to Train Your Dragon (2010) | £17,935 | £17,935 | £17,168,517 | re | 9 |
| 15 (8) |  | Sex and the City 2 (2010) | £15,516 | £39,916 | £21,606,766 | -70% | 9 |