| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Inception (2010) | £5,912,814 | £5,912,814 | £5,912,814 | new | 1 |
| 2 (2) |  | Shrek Forever After (2010) | £4,198,874 | £7,164,102 | £24,397,433 | -9% | 3 |
| 3 (1) |  | The Twilight Saga: Eclipse (2010) | £3,390,512 | £8,343,263 | £22,099,916 | -75% | 2 |
| 4 (3) |  | Predators (2010) | £893,439 | £2,257,680 | £4,460,873 | -59% | 2 |
| 5 (4) |  | Get Him to the Greek (2010) | £440,282 | £1,123,415 | £6,472,238 | -28% | 4 |
| 6 (5) |  | Killers (2010) | £71,486 | £240,608 | £3,196,114 | -55% | 5 |
| 7 (7) | | Heartbreaker (2010) | £68,757 | £174,633 | £469,196 | -19% | 3 |
| 8 (6) |  | Sex and the City 2 (2010) | £51,777 | £178,909 | £21,566,850 | -52% | 8 |
| 9 (12) | | Leaving (2010) | £50,241 | £93,554 | £129,086 | 29% | 2 |
| 10 (new) | | The Concert (2010) | £38,053 | £38,053 | £38,053 | new | 1 |
| 11 (8) |  | I Hate Luv Storys (2010) | £36,679 | £93,924 | £488,550 | -53% | 3 |
| 12 (new) | | Mel Karade Rabba (2010) | £33,995 | £33,995 | £33,995 | new | 1 |
| 13 (11) |  | Tooth Fairy (2010) | £30,235 | £65,491 | £3,741,517 | -35% | 8 |
| 14 (10) |  | Milenge Milenge (2010) | £22,334 | £58,352 | £106,524 | -54% | 2 |
| 15 (9) |  | Prince of Persia: The Sands of Time (2010) | £21,232 | £50,514 | £8,829,805 | -56% | 9 |