| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | The Twilight Saga: Eclipse (2010) | £13,756,653 | £13,756,653 | £13,756,653 | new | 1 |
| 2 (1) |  | Shrek Forever After (2010) | £4,591,105 | £8,277,777 | £17,233,331 | -49% | 2 |
| 3 (new) |  | Predators (2010) | £2,203,193 | £2,203,193 | £2,203,193 | new | 1 |
| 4 (2) |  | Get Him to the Greek (2010) | £610,705 | £1,487,210 | £5,348,823 | -42% | 3 |
| 5 (3) |  | Killers (2010) | £157,615 | £448,977 | £2,955,506 | -43% | 4 |
| 6 (4) |  | Sex and the City 2 (2010) | £107,884 | £399,178 | £21,387,941 | -49% | 7 |
| 7 (6) | | Heartbreaker (2010) | £84,417 | £174,821 | £294,563 | -30% | 2 |
| 8 (5) |  | I Hate Luv Storys (2010) | £78,353 | £191,719 | £394,626 | -61% | 2 |
| 9 (7) |  | Prince of Persia: The Sands of Time (2010) | £48,268 | £165,589 | £8,779,291 | -48% | 8 |
| 10 (new) |  | Milenge Milenge (2010) | £48,172 | £48,172 | £48,172 | new | 1 |
| 11 (12) |  | Tooth Fairy (2010) | £46,482 | £78,759 | £3,676,026 | 3% | 7 |
| 12 (new) | | Leaving (2010) | £35,532 | £35,532 | £35,532 | new | 1 |
| 13 (8) |  | Death At a Funeral (2010) | £31,298 | £125,869 | £2,754,050 | -54% | 6 |
| 14 (16) | | White Material (2010) | £23,285 | £57,425 | £89,188 | -27% | 2 |
| 15 (11) |  | Robin Hood (2010) | £22,135 | £85,880 | £15,381,416 | -52% | 9 |
| 16 (13) |  | StreetDance 3D (2010) | £20,948 | £76,699 | £11,564,899 | -52% | 8 |
| 17 (19) |  | Nanny Mcphee and the Big Bang (2010) | £14,578 | £17,945 | £16,411,169 | 24% | 16 |
| 18 (17) |  | Four Lions (2010) | £14,471 | £36,118 | £2,882,624 | -15% | 10 |
| 19 (new) | | London River (2010) | £12,690 | £12,690 | £12,690 | new | 1 |
| 20 (re) |  | Wild Target (2010) | £6,239 | £6,239 | £762,333 | re | 3 |
| 21 (20) |  | The Killer Inside Me (2010) | £4,082 | £12,961 | £450,205 | -42% | 6 |
| 22 (new) | | Madrasapattinam (2010) | £3,977 | £3,977 | £3,977 | new | 1 |
| 23 (24) |  | The Ghost (2010) | £2,652 | £7,194 | £4,059,493 | 74% | 13 |
| 24 (21) |  | 4.3.2.1 (2010) | £1,675 | £7,555 | £981,527 | -55% | 6 |
| 25 (new) |  | Gangster's Paradise: Jerusalema (2010) | £822 | £822 | £822 | new | 1 |
| 26 (23) |  | Black Death (2010) | £708 | £2,414 | £128,668 | -59% | 5 |
| 27 (new) | | Frownland (2010) | £143 | £143 | £143 | new | 1 |