| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | The Twilight Saga: Eclipse (2010) | £13,756,653 | £13,756,653 | £13,756,653 | new | 1 |
| 2 (1) |  | Shrek Forever After (2010) | £4,591,105 | £8,277,777 | £17,233,331 | -49% | 2 |
| 3 (new) |  | Predators (2010) | £2,203,193 | £2,203,193 | £2,203,193 | new | 1 |
| 4 (2) |  | Get Him to the Greek (2010) | £610,705 | £1,487,210 | £5,348,823 | -42% | 3 |
| 5 (3) |  | Killers (2010) | £157,615 | £448,977 | £2,955,506 | -43% | 4 |
| 6 (4) |  | Sex and the City 2 (2010) | £107,884 | £399,178 | £21,387,941 | -49% | 7 |
| 7 (6) | | Heartbreaker (2010) | £84,417 | £174,821 | £294,563 | -30% | 2 |
| 8 (5) |  | I Hate Luv Storys (2010) | £78,353 | £191,719 | £394,626 | -61% | 2 |
| 9 (7) |  | Prince of Persia: The Sands of Time (2010) | £48,268 | £165,589 | £8,779,291 | -48% | 8 |
| 10 (new) |  | Milenge Milenge (2010) | £48,172 | £48,172 | £48,172 | new | 1 |
| 11 (12) |  | Tooth Fairy (2010) | £46,482 | £78,759 | £3,676,026 | 3% | 7 |
| 12 (new) | | Leaving (2010) | £35,532 | £35,532 | £35,532 | new | 1 |
| 13 (8) |  | Death At a Funeral (2010) | £31,298 | £125,869 | £2,754,050 | -54% | 6 |
| 14 (16) | | White Material (2010) | £23,285 | £57,425 | £89,188 | -27% | 2 |
| 15 (11) |  | Robin Hood (2010) | £22,135 | £85,880 | £15,381,416 | -52% | 9 |