| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Get Him to the Greek (2010) | £1,569,556 | £1,569,556 | £1,569,556 | new | 1 |
| 2 (1) |  | Killers (2010) | £389,509 | £810,762 | £1,863,836 | -63% | 2 |
| 3 (2) |  | Sex and the City 2 (2010) | £357,066 | £976,846 | £20,353,171 | -50% | 5 |
| 4 (4) |  | Prince of Persia: The Sands of Time (2010) | £159,684 | £321,258 | £8,356,964 | -59% | 6 |
| 5 (3) |  | StreetDance 3D (2010) | £159,260 | £319,486 | £11,280,062 | -66% | 6 |
| 6 (6) |  | Death At a Funeral (2010) | £118,648 | £286,569 | £2,414,942 | -59% | 4 |
| 7 (new) | | The Collector (2010) | £109,519 | £109,519 | £109,519 | new | 1 |
| 8 (5) |  | Letters to Juliet (2010) | £104,134 | £307,038 | £1,770,149 | -66% | 3 |
| 9 (9) |  | Robin Hood (2010) | £89,457 | £218,111 | £15,104,421 | -63% | 7 |
| 10 (7) |  | Wild Target (2010) | £88,287 | £260,836 | £543,334 | -69% | 2 |
| 11 (8) |  | Tooth Fairy (2010) | £78,171 | £124,360 | £3,499,833 | -69% | 5 |
| 12 (10) |  | Brooklyn's Finest (2010) | £76,274 | £189,182 | £1,125,050 | -62% | 3 |
| 13 (new) | | Whatever Works (2010) | £72,678 | £72,678 | £72,678 | new | 1 |
| 14 (new) |  | When In Rome (2010) | £61,512 | £61,512 | £61,512 | new | 1 |
| 15 (11) |  | Raavan (2010) | £27,230 | £74,905 | £200,035 | -78% | 2 |
| 16 (18) |  | Four Lions (2010) | £17,829 | £40,681 | £2,808,859 | -52% | 8 |
| 17 (new) | | Tetro (2010) | £11,770 | £11,770 | £11,770 | new | 1 |
| 18 (20) |  | The Killer Inside Me (2010) | £10,442 | £27,571 | £411,571 | -61% | 4 |
| 19 (17) |  | 4.3.2.1 (2010) | £10,242 | £28,497 | £954,842 | -74% | 4 |
| 20 (new) | | Good Hair (2010) | £5,644 | £5,644 | £5,644 | new | 1 |
| 21 (22) |  | Black Death (2010) | £3,056 | £12,489 | £120,018 | -81% | 3 |
| 22 (27) |  | Nanny Mcphee and the Big Bang (2010) | £2,239 | £2,364 | £16,381,405 | -29% | 14 |
| 23 (new) |  | Villa Amalia (2010) | £2,152 | £2,152 | £2,152 | new | 1 |
| 24 (29) |  | American: The Bill Hicks Story (2010) | £575 | £2,561 | £116,289 | -71% | 7 |
| 25 (28) |  | The Ghost (2010) | £246 | £3,629 | £4,050,948 | -90% | 11 |
| 26 (33) | | The Infidel (2010) | £94 | £380 | £590,078 | 52% | 12 |