| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (1) |  | Sex and the City 2 (2010) | £2,473,043 | £7,509,334 | £13,652,052 | -60% | 2 |
| 2 (2) |  | StreetDance 3D (2010) | £1,144,239 | £3,671,902 | £8,964,747 | -37% | 3 |
| 3 (3) |  | Prince of Persia: The Sands of Time (2010) | £821,661 | £2,344,999 | £6,362,459 | -50% | 3 |
| 4 (new) |  | Death At a Funeral (2010) | £696,280 | £696,280 | £696,280 | new | 1 |
| 5 (4) |  | Robin Hood (2010) | £647,195 | £1,912,044 | £13,532,135 | -57% | 4 |
| 6 (5) |  | Tooth Fairy (2010) | £538,366 | £1,595,585 | £2,440,474 | -36% | 2 |
| 7 (new) |  | 4.3.2.1 (2010) | £433,218 | £433,218 | £433,218 | new | 1 |
| 8 (new) |  | She's Out of My League (2010) | £400,554 | £400,554 | £400,554 | new | 1 |
| 9 (6) |  | Iron Man 2 (2010) | £226,314 | £710,990 | £20,686,508 | -56% | 6 |
| 10 (7) |  | Space Chimps 2: Zartog Strikes Back (2010) | £220,989 | £822,247 | £1,257,130 | -49% | 2 |
| 11 (new) | | Raajneeti (2010) | £218,783 | £218,783 | £218,783 | new | 1 |
| 12 (new) |  | The Killer Inside Me (2010) | £124,006 | £124,006 | £124,006 | new | 1 |
| 13 (8) |  | The Losers (2010) | £110,255 | £496,395 | £888,333 | -72% | 2 |
| 14 (11) |  | Furry Vengeance (2010) | £91,042 | £354,260 | £3,301,901 | -42% | 5 |
| 15 (10) |  | Four Lions (2010) | £83,609 | £223,835 | £2,562,809 | -49% | 5 |
| 16 (new) |  | The Brother's Bloom (2010) | £36,861 | £36,861 | £36,861 | new | 1 |
| 17 (17) |  | Nanny Mcphee and the Big Bang (2010) | £11,160 | £80,550 | £16,362,249 | -74% | 11 |
| 18 (new) |  | The Girl On the Train (2010) | £10,980 | £10,980 | £10,980 | new | 1 |
| 19 (18) |  | The Ghost (2010) | £7,253 | £24,449 | £4,021,475 | -57% | 8 |
| 20 (new) |  | Videocracy (2010) | £4,801 | £4,801 | £4,801 | new | 1 |
| 21 (20) |  | American: The Bill Hicks Story (2010) | £2,866 | £16,757 | £94,577 | -76% | 4 |
| 22 (23) |  | Kick-Ass (2010) | £2,077 | £5,553 | £11,594,478 | -16% | 10 |
| 23 (24) | | The Infidel (2010) | £1,667 | £2,028 | £584,689 | -5% | 9 |
| 24 (new) | | Kicks (2010) | £977 | £977 | £977 | new | 1 |
| 25 (22) |  | The Disappearance of Alice Creed (2010) | £683 | £4,586 | £389,542 | -81% | 6 |
| 26 (new) |  | Shrink (2010) | £409 | £409 | £409 | new | 1 |
| 27 (28) |  | No Greater Love (2010) | £357 | £1,058 | £26,464 | 71% | 9 |
| 28 (27) | | Crying With Laughter (2010) | £77 | £685 | £10,900 | -80% | 7 |
| 29 (25) |  | It's a Wonderful Afterlife (2010) | £54 | £2,085 | £1,017,758 | -95% | 7 |