| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Dear John (2010) | £1,995,301 | £1,995,301 | £1,995,301 | new | 1 |
| 2 (1) |  | Clash of the Titans (2010) | £1,557,034 | £3,617,508 | £16,273,543 | -36% | 3 |
| 3 (2) |  | How to Train Your Dragon (2010) | £1,282,519 | £3,306,626 | £13,089,419 | -8% | 3 |
| 4 (3) |  | Kick-Ass (2010) | £910,453 | £2,039,584 | £9,040,664 | -24% | 3 |
| 5 (4) |  | Nanny Mcphee and the Big Bang (2010) | £866,940 | £2,660,495 | £14,566,583 | -27% | 4 |
| 6 (new) |  | The Ghost (2010) | £853,679 | £853,679 | £853,679 | new | 1 |
| 7 (5) |  | Alice In Wonderland (2010) | £498,948 | £1,339,408 | £41,423,309 | -26% | 7 |
| 8 (6) |  | The Blind Side (2010) | £299,079 | £726,814 | £5,630,136 | -44% | 4 |
| 9 (7) |  | Remember Me (2010) | £225,397 | £723,505 | £3,363,390 | -57% | 3 |
| 10 (new) |  | Repo Men (2010) | £182,798 | £182,798 | £182,798 | new | 1 |
| 11 (9) |  | Shutter Island (2010) | £179,237 | £392,532 | £10,431,136 | -47% | 6 |
| 12 (14) | | The Infidel (2010) | £120,251 | £184,757 | £320,205 | -11% | 2 |
| 13 (11) | | Io Sono L'amore (2010) | £113,343 | £232,096 | £404,055 | -34% | 2 |
| 14 (13) |  | The Spy Next Door (2010) | £105,713 | £278,436 | £2,584,033 | -23% | 5 |
| 15 (new) | | Paathshala (2010) | £26,432 | £26,432 | £26,432 | new | 1 |
| 16 (16) | | Perriers Bounty (2010) | £12,422 | £27,047 | £316,477 | -35% | 4 |
| 17 (17) |  | Planet 51 (2009) | £8,183 | £9,135 | £5,022,790 | 3% | 19 |
| 18 (19) |  | Exit Through the Gift Shop (2010) | £5,462 | £7,453 | £300,716 | 44% | 7 |
| 19 (new) | | The Heavy (2010) | £5,137 | £5,137 | £5,137 | new | 1 |
| 20 (new) | | City of Life and Death (2010) | £4,790 | £4,790 | £4,790 | new | 1 |
| 21 (new) | | Crying With Laughter (2010) | £3,647 | £3,647 | £3,647 | new | 1 |
| 22 (new) |  | The Market (2010) | £1,975 | £1,975 | £1,975 | new | 1 |
| 23 (20) |  | No Greater Love (2010) | £1,663 | £4,530 | £6,983 | -32% | 2 |
| 24 (18) |  | An Education (2009) | £1,510 | £5,408 | £2,525,622 | -53% | 23 |
| 25 (23) | | |