| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Click (2006) | £1,797,073 | £1,797,073 | £1,797,073 | new | 1 |
| 2 (new) |  | Hoodwinked (2006) | £1,764,419 | £1,764,419 | £1,764,419 | new | 1 |
| 3 (new) |  | World Trade Center (2006) | £1,667,589 | £1,667,589 | £1,667,589 | new | 1 |
| 4 (1) |  | Children of Men (2006) | £957,119 | £1,694,291 | £2,978,545 | -25% | 2 |
| 5 (2) |  | The Queen (2006) | £803,371 | £1,656,015 | £4,314,538 | -12% | 3 |
| 6 (3) |  | Talladega Nights: The Ballad of Ricky Bobby (2006) | £336,082 | £636,771 | £2,918,584 | -51% | 3 |
| 7 (6) |  | Little Miss Sunshine (2006) | £284,521 | £528,067 | £2,195,035 | -23% | 4 |
| 8 (4) |  | Little Man (2006) | £228,793 | £360,998 | £4,045,671 | -50% | 5 |
| 9 (5) |  | You, Me and Dupree (2006) | £194,244 | £384,056 | £7,879,447 | -55% | 6 |
| 10 (7) |  | The Black Dahlia (2006) | £126,769 | £328,021 | £1,571,991 | -62% | 3 |
| 11 (9) |  | Dirty Sanchez: The Movie (2006) | £111,765 | £264,751 | £521,785 | -57% | 2 |
| 12 (new) |  | Life and Lyrics (2006) | £95,724 | £95,724 | £95,724 | new | 1 |
| 13 (12) |  | An Inconvenient Truth (2006) | £90,029 | £194,771 | £437,215 | -26% | 2 |
| 14 (11) |  | Monster House (2006) | £77,246 | £93,517 | £6,442,056 | -38% | 8 |
| 15 (8) |  | Trust the Man (2006) | £73,186 | £252,095 | £533,024 | -74% | 2 |