| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (2) |  | Cars (2006) | £1,340,219 | £3,127,085 | £10,628,957 | -27% | 3 |
| 2 (3) |  | Pirates of the Caribbean: Dead Man's Chest (2006) | £1,320,059 | £2,844,418 | £46,386,997 | -22% | 6 |
| 3 (1) |  | Miami Vice (2006) | £1,186,987 | £2,509,134 | £4,740,818 | -47% | 2 |
| 4 (new) |  | Monster House (2006) | £1,030,305 | £1,030,305 | £1,030,305 | new | 1 |
| 5 (new) |  | Nacho Libre (2006) | £993,948 | £993,948 | £993,948 | new | 1 |
| 6 (new) |  | Kabhi Alvida Naa Kehna (2006) | £749,243 | £749,243 | £749,243 | new | 1 |
| 7 (4) |  | The Break Up (2006) | £554,633 | £1,283,681 | £8,887,257 | -30% | 4 |
| 8 (5) |  | My Super Ex-Girlfriend (2006) | £486,043 | £1,183,072 | £1,897,992 | -32% | 2 |
| 9 (new) |  | Lady In the Water (2006) | £452,744 | £452,744 | £452,744 | new | 1 |
| 10 (6) |  | Superman Returns (2006) | £407,580 | £993,490 | £14,891,000 | -42% | 5 |
| 11 (9) |  | Garfield 2 (2006) | £316,712 | £783,439 | £4,032,695 | -13% | 4 |
| 12 (7) |  | Stormbreaker (2006) | £278,545 | £805,034 | £5,354,092 | -31% | 4 |
| 13 (8) |  | The Ant Bully (2006) | £209,393 | £678,281 | £1,061,047 | -45% | 2 |
| 14 (10) |  | Over the Hedge (2006) | £153,142 | £427,894 | £12,086,727 | -23% | 7 |
| 15 (11) |  | The Wind That Shakes the Barley (2006) | £89,761 | £199,133 | £3,199,967 | -1% | 8 |