| Title | Weekend | Week | Total | % Change | Total Weeks |
| 1 (new) |  | Me, Myself & Irene (2000) | £1,292,512 | £1,292,512 | £1,292,512 | new | 1 |
| 2 (1) |  | Scary Movie (2000) | £1,030,523 | £1,798,204 | £7,229,934 | -29% | 3 |
| 3 (2) |  | Snatch (2000) | £811,470 | £1,475,439 | £10,019,674 | -26% | 4 |
| 4 (new) |  | Space Cowboys (2000) | £567,885 | £567,885 | £567,885 | new | 1 |
| 5 (3) |  | Shaft (2000) | £565,568 | £1,026,940 | £1,899,485 | -35% | 2 |
| 6 (4) |  | O Brother, Where Art Thou? (2000) | £456,832 | £771,339 | £1,335,403 | -19% | 2 |
| 7 (5) |  | The Cell (2000) | £341,141 | £635,023 | £1,189,337 | -38% | 2 |
| 8 (6) |  | X-Men (2000) | £262,698 | £447,526 | £14,512,151 | -37% | 6 |
| 9 (9) |  | Stuart Little (2000) | £188,997 | £218,865 | £16,906,246 | -6% | 13 |
| 10 (8) |  | Chicken Run (2000) | £185,837 | £236,882 | £28,352,392 | -11% | 13 |
| 11 (7) |  | Keeping the Faith (2000) | £145,518 | £286,383 | £548,270 | -44% | 2 |
| 12 (14) |  | The Flintstones In Viva Rock Vegas (2000) | £53,158 | £59,000 | £2,005,246 | 7% | 9 |
| 13 (11) | | Fiza (2000) | £39,376 | £63,641 | £320,162 | -42% | 3 |
| 14 (13) | | Dancer In the Dark (2000) | £36,511 | £65,957 | £115,953 | -27% | 2 |
| 15 (re) |  | Gladiator (2000) | £34,945 | £34,945 | £30,907,687 | re | 19 |